Comparison of IgG antibodies, SARS-CoV-2 load, and prognostic indicators in patients with severe and mild COVID-19 in Japan.

Comparison of IgG antibodies, SARS-CoV-2 load, and prognostic indicators in patients with severe and mild COVID-19 in Japan. J Nippon Med Sch. 2020 Nov 30;: Authors: Kashiwagi K, Maeda T, Yoshizawa S, Sato T, Aoki K, Ishii Y, Tateda K Abstract We assessed the relationship between disease severity and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load, IgG antibody levels, and prognostic indicators. Twenty-one patients hospitalized with COVID-19 were classified as having severe or mild disease based on their average respiratory rate during hospitalization (severe: ≥22 breaths/min; mild: <22 breaths/min). The viral load in nasopharyngeal samples, and blood levels of C-reactive protein (CRP), lymphocytes, and D-dimer on admission and plasma immunoglobulin G (IgG) index on Day 7 ±2 from symptom onset were compared according to disease severity. Of the participants, 7 had severe and 14 had mild disease. Participants with severe disease had a significantly higher IgG index (median: 3.75 vs 0.56, p=0.01), CRP (median: 8.6 vs 1.0 mg/dL, p<0.001), and D-dimer levels (median: 1.65 vs 0.75μg/mL; p=0.002), and a significantly lower lymphocyte count (median: 1176 vs 666 cells/μL, p=0.005) and viral load (median: 8.7×106 vs 2.3×104 copies/mL, p=0.005). Furthermore, time from symptom onset to virus disappearance was significantly longer (median: 24 vs 17 days, p=0.03). A high IgG index in the early phase of the disease m...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research