Type 2 Inflammation in the Sputum of Adolescents with Asthma

Type 2 (T2) inflammation, which includes cytokines interleukin (IL)-4, -5 and -13, is a major molecular mechanism in asthma pathogenesis. While extensively studied in adults, pediatric-specific data on these pathways in children with asthma are limited1-4. The Severe Asthma Research Program (SARP), a longitudinal cohort study with 7 US clinical sites, enrolled children 6-17 years of age with asthma, who underwent detailed characterization and collection of various biomarkers to understand the molecular mechanisms of the different asthma endotypes.

https://www.annallergy.org/article/S1081-1206(20)31221-7/fulltext?rss=yes

Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Andrea M. Coverstone, Jonathan S. Boomer, Daphne Lew, Leonard B. Bacharier, Mario Castro, Severe Asthma Research Program (SARP) Investigators Tags: Letters Source Type: research