Targeting the myeloid checkpoint receptor SIRP α potentiates innate and adaptive immune responses to promote anti-tumor activity
Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons and Hong I. Wan Tags: Research Source Type: research
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