Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage.

CONCLUSIONS: Long-term cold storage induces mitochondrial uncoupling and increased proton leak and ROS generation. The resulting ROS is a crucial contributor to the increased macrophage-dependent and -independent clearance of functional PLTs and can be prevented by the antioxidant NAC in a magnesium-containing additive solution. PMID: 33247486 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33247486?dopt=Abstract

Source: Transfusion - November 27, 2020 Category: Hematology Authors: Hegde S, Wellendorf AM, Zheng Y, Cancelas JA Tags: Transfusion Source Type: research