Report highlights the dangers of opioid painkillers
Whenever I read or write about the overuse of so-called opioid painkillers it is with mixed feelings. As a lifelong back-pain patient who once depended on them for pain relief, I appreciate the challenge posed by opioids to people in pain and their doctors. People in agonizing pain want it to stop, but opioids are often a poor long-term solution. Doctors want to help their patients, so they may prescribe opioids for extended periods despite well-founded reservations. At the same time, the epidemic of abuse of these painkillers has led to numerous deaths. Like many Americans, I know people whose lives were destroyed—who ended up in rehab, the legal system, or the grave—because of prescription painkiller abuse. An article this week in the New England Journal of Medicine pegs the toll at nearly 17,000 fatalities in 2010. Hydrocodone (Vicodin) and oxycodone (Oxycontin, Percocet, Percodan) are the most widely used and abused of the opioids. Others in this family of drugs are codeine, fentanyl (Duragesic patch), hydromorphone (Dilaudid), meperidine (Demerol), morphine (MS Contin), and tramadol (Ultram). These drugs block pain perception in the brain. Doctors are learning to say no to opioids, but at the same time have limited scientific guidance on when and how to best use opioids for chronic pain, according to a report published online in the Annals of Internal Medicine this week by a National Institute of Health expert panel. It follows on the heels of a position stat...
I'm currently working in a small private practice group and just wondering if people are applying for the EIDL 10,000$ advance (grant?) vs the PPP loan which can be forgiven up to about 100k/12months x 2.5 (about 20.8k), or applied for both?
CONCLUSIONS These results indicate that GDLP against T2DM-induced hepatic steatosis, oxidative stress, and inflammation by improving the Nrf2/HO-1 signaling pathway in db/db mice, suggesting the GDLP may serve as an effective strategy for in fatty liver treatment. PMID: 32245940 [PubMed - as supplied by publisher]
Is sugammadex preferable to neostigmine for neuromuscular blockade reversal in terms of 90-day mortality after non-cardiac surgery?BMC Anesthesiology
Foods high in soluble fiber like oatmeal, nuts and beans were associated with reduced breast cancer incidence.
Conclusions: Craniomaxillofacial metastases, usually with multiple visceral or axial skeleton lesions, have an ominous prognosis. Multidisciplinary management could benefit the patient status and lead to more favourable outcomes. There are exceptional cases of long-term survival.RESUMEN Objetivo: Estudio descriptivo retrospectivo de 21 casos de met ástasis en tejidos blandos orales y/o huesos maxilares. Material y métodos: Revisión a 12 años de actas de nuestro departamento, excluyendo procesos linfoproliferativos, metástasis cutáneas, glándulas salivales, otros huesos crane...
Conclusiones: Las incisiones mínimamente invasivas constituyen una alternativa eficaz, segura y con escasas morbilidades para el drenaje de infecciones cervicales profundas.ABSTRACT Aim: Most of deep cervical infections are polymicrobial and come from a dental origin, and an appropriate treatment is necessary. The present paper aims to describe the efficiency of minimally invasive incisions for the drainage of deep cervical infections. Materials and methods: A descriptive, retrospective and longitudinal study in patients with deep cervical infections, who required hospital admission. Patients were surgically treated...
RESUMEN Introducci ón: El manejo odontológico de pacientes médicamente comprometidos requiere un enfoque integral y multidisciplinario. La hipoxemia puede presentarse en pacientes odontológicos con enfermedades respiratorias durante y después de la intervención, por lo que se requiere la monitorización del porc entaje de saturación de oxígeno en sangre periférica (%SpO2) para identificar rápidamente aquellos trastornos que precisen intervención terapéutica. La enfermedad pulmonar obstructiva crónica (EPOC) es una enfermedad qu...
Publication date: Available online 4 April 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Kaili Wang, Weijie Zhang, Zihan Wang, Ming Gao, Xinying Wang, Wenchao Han, Nan Zhang, Xia Xu
Publication date: Available online 5 April 2020Source: Seminars in Cancer BiologyAuthor(s): Emad A. Rakha, Fresia G. Pareja
Publication date: Available online 4 April 2020Source: Seminars in Cancer BiologyAuthor(s): Michela Biancolella, Barbara Testa, Leila Baghernajad Salehi, Maria Rosaria D’Apice, Giuseppe Novelli
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