P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration.

CONCLUSION: PSGL-1 deficiency effectively inhibits the development of AP by preventing leukocyte-endothelial cell adhesion via IL-6 stimulation and may become a potential therapeutic target for treating AP.
PMID: 33244198 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - November 7, 2020 Category: Gastroenterology Authors: Zhang X, Zhu M, Jiang XL, Liu X, Liu X, Liu P, Wu XX, Yang ZW, Qin T Tags: World J Gastroenterol Source Type: research