Genomic patterns and characterizations of chromosomally-encoded mcr - 1 in Escherichia coli populations

In this study, we systematically investigated the genetic basis of chromosomally-encodedmcr-1 in prevalence and potential mechanisms of lineage, plasmid, insertion sequence, and phage. Our results demonstrated that the emergence of chromosomally-encodedmcr-1 could originate from multiple mechanisms, but mainly derived through the recombination of ISApl1/Tn6330. We reported a specific transmission mechanism, which is a phage-like region without lysogenic components, could associate with the emergence and stabilization of chromosomally-encodedmcr-1. These results highlighted the potential origin and risks of chromosomally-encodedmcr-1, which could be a heritable repository and thrive again when confronted with new selective pressures. To the best of our knowledge, this is the first study to systematically reveal the genomic basis of chromosomally-encodedmcr-1, and report a specific transmission pattern involved in phage-like region. Overall, we demonstrate the origin mechanisms and risks of chromosomally-encodedmcr-1. It highlights the need of public attention on chromosome-encodedmcr-1 to prevent from its reemergence.
Source: Gut Pathogens - Category: Microbiology Source Type: research