15936 In lieu of penectomy: Complete resolution of invasive penile melanoma and melanoma in situ with topical imiquimod

A 69-year-old Caucasian man with no personal or family history of skin cancer presented with a 15-month history of an enlarging 2.5 × 2.3 cm ulcerated, irregularly brown pigmented lesion with a central whitish-blue nodule on the distal right penis shaft without groin adenopathy. Diagnostic biopsy demonstrated invasive melanoma. Excision demonstrated invasion to 1.76 mm, 3 mitoses per mm2, melanoma in situ (MIS) at the margins. Bilateral inguinal lymph node biopsies were negative. Given the Breslow depth and residual MIS, urology and surgical oncology recommended definitive removal via penectomy.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research