2-Azidoacrylamides as compact platforms for efficient modular synthesis.

2-Azidoacrylamides as compact platforms for efficient modular synthesis.
Chem Commun (Camb). 2020 Nov 26;:
Authors: Takemura H, Goto S, Hosoya T, Yoshida S
Abstract
Efficient methods to assemble modules with compact platform molecules by triazole formations and Michael reactions are disclosed. The good electrophilicity of 2-triazolylacrylamides realized Michael additions using various nucleophiles. An iterative synthesis of a tetrakis(triazole) was accomplished by orthogonal triazole formations and Michael reactions.
PMID: 33241832 [PubMed - as supplied by publisher]

Source: Chemical Communications - November 26, 2020 Category: Chemistry Authors: Takemura H, Goto S, Hosoya T, Yoshida S Tags: Chem Commun (Camb) Source Type: research