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We were pleased to receive the comments by Koyama and Sairenchi regarding our recent review of fetal growth restriction (FGR) and programmed hypertension. We agree that rapid weight gain, development of obesity, and high sodium intake during the first year of life and throughout childhood are likely major factors that further promote hypertension development in children with FGR in an additive or even multiplicative fashion, mediated in part through renin-angiotensin-system (RAS) alterations (Figure; available at www.jpeds.com) (3-8).

Source: The Journal of Pediatrics - November 27, 2020 Category: Pediatrics Authors: Andrew M. South, Barbara T. Alexander, Janna L. Morrison, Arvind Sehgal Tags: Letters to the Editor Source Type: research