Study on the additive protective effect of PGLYRP3 and Bifidobacterium adolescentis Reuter 1963 on severity of DSS-induced colitis in Pglyrp3 knockout (Pglyrp3 -/-) and wild-type (WT) mice.
This study shows that Pglyrp3 facilitates recognition of bifidobacterial cell wall-derived peptidoglycan, thus leading additively to a reduction of metaflammation through an increase in the number of bifidobacteria, which were able to mitigate intestinal immunopathology in the context of Pglyrp3 blockade.
PMID: 33242664 [PubMed - as supplied by publisher]
Source: Immunobiology - Category: Allergy & Immunology Authors: Ghadimi D, de Vrese M, Ebsen M, Röcken C, Olaf Frahm S, Zahlten J, Fölster-Holst R, Heller KJ, Bockelmann W Tags: Immunobiology Source Type: research
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