Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration.

CONCLUSION: Cit-ITIH4 is generated mainly in inflamed joints by neutrophils via PAD4. Citrullination of ITIH4 may change its function to upregulate neutrophilic migration by activating the complement cascade, exacerbating arthritis.
PMID: 33238047 [PubMed - as supplied by publisher]

Source: Clinical and Developmental Immunology - November 25, 2020 Category: Allergy & Immunology Authors: Osada A, Matsumoto I, Mikami N, Ohyama A, Kurata I, Kondo Y, Tsuboi H, Ishigami A, Sano Y, Arai T, Ise N, Sumida T Tags: Clin Exp Immunol Source Type: research