Cannabinoids in the Treatment of Insomnia Disorder: A Systematic Review and Meta-Analysis

ConclusionsFew studies have examined the efficacy of cannabinoids in the treatment of insomnia disorder. Despite some possible signals for efficacy, the heterogeneity of participants, interventions, efficacy outcomes and results, and the high risk of bias across included trials, do not reliably inform evidence-based practice. This review highlights shortcomings in the existing literature, including lack of diagnostic clarity, poorly defined participant groups, non-standardised interventions and studies of inappropriate design, duration and power to detect clinically meaningful outcomes. Further research in the form of high-quality RCTs are required before drawing any conclusions about the efficacy of cannabinoids in the treatment of insomnia disorder.Trial RegistrationPROSPERO registration number, CRD42020161043.
Source: CNS Drugs - Category: Neurology Source Type: research