Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method.

Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method.
Chem Commun (Camb). 2020 Nov 24;:
Authors: Bains AK, Biswas A, Adhikari D
Abstract
An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcohols following "borrowing hydrogen". A one-pot, cascade C3-alkylation starting from 2-aminophenyl ethyl alcohols, and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal-ligand bifunctionality.
PMID: 33231589 [PubMed - as supplied by publisher]

Source: Chemical Communications - November 24, 2020 Category: Chemistry Authors: Bains AK, Biswas A, Adhikari D Tags: Chem Commun (Camb) Source Type: research