Reply

We appreciate Xu et al for the external validation of the NASH PT score that we developed for identifying nonalcoholic steatohepatitis (NASH) among the diverse spectra of nonalcoholic fatty liver disease (NAFLD).1 The NASH PT score is a polygenic risk scoring model incorporating 2 genetic risk factors, PNPLA3 rs73840 9 and TM6SF2 rs58542926. We developed it from the biopsy-proven NAFLD cohort (n = 302) and validated it using an independent replication dataset (n = 151).1 The area under the receiver operating characteristic curve in the replication cohort was 0.787 (95% confidence interval, 0.715–0.860), whic h was significantly better than the NASH score based on only 1 single-nucleotide polymorphism, PNPLA3 rs738409.

https://www.cghjournal.org/article/S1542-3565(20)30589-9/fulltext?rss=yes

Source: Clinical Gastroenterology and Hepatology - November 25, 2020 Category: Gastroenterology Authors: Bo Kyung Koo, Won Kim Tags: Letter to the Editor Source Type: research