Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.

CONCLUSIONS: We describe a novel pathogenic link between TH deficiency and CGD and suggest that the increased hydrophobic character of biliary BAs due to the diminished expression of hepatic detoxification enzymes promotes cholesterol crystal precipitation and finally enhances cholesterol gallstone formation in the bile of hypothyroid mice. PMID: 33231505 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research