Cholangiocarcinoma: Bridging the translational gap from preclinical to clinical development and implications for future therapy.

Cholangiocarcinoma: Bridging the translational gap from preclinical to clinical development and implications for future therapy. Expert Opin Investig Drugs. 2020 Nov 23;: Authors: Baiocchi L, Sato K, Ekser B, Kennedy L, Francis H, Ceci L, Lenci I, Alvaro D, Franchitto A, Onori P, Gaudio E, Wu C, Chakraborty S, Glaser S, Alpini G Abstract INTRODUCTION: Cholangiocarcinoma (CCA) is a devastating liver tumor with a poor prognosis. While less than 50% of patients with CCA may benefit from surgical resection, the rest undergoes chemotherapy with disappointing results (mean survival <2 years). Alternative pharmacological treatments are needed to improve the outcomes in patients with CCA. AREAS COVERED: In this review, we discuss CCA-related: i) experimental systems used in preclinical studies; ii) pharmacological targets identified by genetic analysis; iii) results obtained in preliminary trials in human with their pros and cons; and iv) possible targeting of endocrinal modulation. A PubMed bibliographic search matching the term "cholangiocarcinoma" with "experimental model", "preclinical model", "genetic target", "targeted therapy", "clinical trial" or "translational research" was conducted and manuscripts published between 2010 and 2020 were retrieved for reading and reviewing. EXPERT OPINION: Several factors contribute to the translational gap between bench research and clinical practice in CCA. The tumor heterogeneity...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research