Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3'-quinoline] derivatives.

Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3'-quinoline] derivatives.
Chem Commun (Camb). 2020 Nov 23;:
Authors: Zhang J, Xu W, Qu Y, Liu Y, Li Y, Song H, Wang Q
Abstract
Herein, we report the first protocol for visible-light-induced radical isocyanide insertion reactions between 3-(2-isocyanobenzyl)-indoles and bromodifluoroacetates or bromodifluoroacetamides. The protocol, which has good functional group tolerance and a broad substrate scope, constitutes an efficient and general route to difluoromethylated spiro[indole-3,3'-quinoline] derivatives.
PMID: 33227101 [PubMed - as supplied by publisher]

Source: Chemical Communications - November 23, 2020 Category: Chemistry Authors: Zhang J, Xu W, Qu Y, Liu Y, Li Y, Song H, Wang Q Tags: Chem Commun (Camb) Source Type: research