COVID-19: A data challenge and a catalyst for new insights

  One of the key issues that arose during the pandemic, and arguably a factor that has led to more deaths, has been one of healthcare systems, public health and governments having insufficient or no relevant data on which to base critical decisions. The right data are not in the right place to answer the right questions at the right time. Yet, in the midst of this we have also seen remarkable collaboration on the scientific response to the pandemic, from diagnostics to therapeutic and vaccine research and development. We have learned a lot about the virus since its genome was shared by Chinese researchers in January.   Evidence at scale and at speed A very significant learning has been the need for real world, observational data, in the right hands, to research applicable insights from the past, contemporary insights from today, and implications for the future management of pandemics.    Studies of existing knowledge, such as the Observational Health Data Sciences and Informatics (OHDSI) study-a-thon held in March and characterising the adverse event profile of hydroxychloroquine in rheumatoid patients, as well as international observational and randomised trials of its lack of efficacy in COVID-19 treatment.    Thestudy-a-thon is ongoing, transitioning into the SCYLLA and CHARYBDIS studies. They have produced manuscripts published or in preprint on hydroxychloroquine, but also on the role of antihypertensives in COVID-19 patients, ...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news

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ConclusionsResults show the importance of establishing and maintaining ongoing contact among the preventive services, primary care providers and the population since trust is difficult to establish during an emergency.Key messagesOn of the most important finding for public health prevention efforts was the importance of influenza vaccine in predicting COVID.Having an agile system that can monitor changing attitudes will be important to altering the messaging and identifying changes in the characteristics of those hesitant or unwilling to be vaccinated.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Abstract Influenza is an acute viral respiratory infection that causes significant morbidity and mortality worldwide, with indirect costs considerably exceeding direct costs on patients and society. Flu vaccination is one of the major strategies for preventing it, especially among healthcare workers (HCWs), to avoid onward transmission to patients and colleagues. The aim of this research is to analyze the flu vaccination coverage rate among HCWs and to study which factors conditioned their adherence. The observational study was conducted in an Italian teaching hospital located in Rome (Italy) and data were collected f...
Source: The European Journal of Public Health - Category: General Medicine Source Type: research
Background: It is just over a century since the 1918 flu pandemic, sometimes referred to as the “mother” of pandemics. This brief retrospective of the 1918 pandemic is taken from the viewpoint of the current SARS-CoV-2/COVID-19 pandemic and is based on a short lecture given during the 2021 Virtual Congress of the ERA-EDTA.Summary: This review summarizes and highlights some of the earlier pandemic ’s salient features, some parallels with today, and some potential learnings, bearing in mind that the flu pandemic occurred over 100 years ago at a time of major turmoil during the climax to WWl, and with limite...
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
J Sleep Res. 2021 Oct 6:e13496. doi: 10.1111/jsr.13496. Online ahead of print.ABSTRACTThis protocol describes an innovative study to investigate the relationship between sleep, shift work and the immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; coronavirus disease 2019 [COVID-19]) vaccination. As the COVID-19 pandemic is a global crisis with devastating health, social and economic impacts, there is a pressing need for effective vaccination programmes. Previous influenza and hepatitis vaccination studies suggest that lack of sleep can negatively alter immune responsiveness, while circadian mis...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
Med Sci Monit. 2021 Oct 4;27:e934949. doi: 10.12659/MSM.934949.ABSTRACTThere have been five viral pandemics in the past century, four were due to influenza, and the ongoing COVID-19 pandemic is due to SARS-CoV-2 infection. During the COVID-19 pandemic, there has been a 99% global reduction in the diagnosis of influenza. Also, from 2020, global mortality rates from influenza fell to record levels during the influenza seasons in the southern and northern hemispheres. However, as social restrictions become lifted and the winter season begins in the northern hemisphere, it is expected that influenza will re-emerge. The World H...
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
Infect Genet Evol. 2021 Oct 1:105097. doi: 10.1016/j.meegid.2021.105097. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 pathogen, has led to waves of global pandemic claiming lives and posing a serious threat to public health and social cum physical interactions. To evaluate the mutational landscape and conserved regions in the genome of the causative pathogen, we analysed 7213 complete SARS-CoV-2 protein sequences mined from the Global Initiative on Sharing All Influenza Data (GISAID) repository from infected patients across all regions on the EpiCov web interface. Regions of origi...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Source Type: research
On Sept. 7, the country’s leading COVID-19 doctor issued a dire warning about the growing number of pandemic cases in the country, and the shrinking number of ICU beds available to care for the sickest people. Speaking on CNN, Dr. Anthony Fauci, the chief White House medical advisor, said we are “perilously close in certain areas of the country of getting so close to having full occupancy that you’re going to be in a situation where you’re going to have to make some tough choices.” Those tough choices, he admitted, include discussions about whether scarce resources should go to people who have...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
This report updates the 2020-21 recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the United States (MMWR Recomm Rep 2020;69[No. RR-8]). Routine annual influenza vaccination is recommended for all persons aged ≥6 months who do not have contraindications. For each recipient, a licensed and age-appropriate vaccine should be used. ACIP makes no preferential recommendation for a specific vaccine when more than one licensed, recommended, and age-appropriate vaccine is available. During the 2021-22 influenza season, the following types of vaccines ar...
Source: MMWR Recomm Rep - Category: Epidemiology Authors: Source Type: research
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