Myeloid-derived Interleukin-33 limits the severity of dextran sulfate sodium (DSS)-induced colitis

Interleukin (IL)-33 is an IL-1 family cytokine that signals through its cognate receptor ST2 to regulate inflammation. It is controversial whether IL-33 serves pathogenic or protective role during inflammatory bowel disease (IBD). Here, two different strains of cell-specific conditionally deficient mice were used to compare the role of myeloid- versus intestinal epithelial cell (IEC)-derived IL-33 during dextran sodium sulfate-induced colitis. Data show that loss of CD11c-restricted IL-33 exacerbated tissue pathology coinciding with increased tissue Il6 levels and loss of intestinal Foxp3+Treg, but surprisingly, the lack of IEC-derived IL-33 had no impact on disease severity or tissue recovery.

Source: American Journal of Pathology - November 23, 2020 Category: Pathology Authors: Li-Yin Hung, Christopher F. Pastore, Bonnie Douglas, De ’Broski R. Herbert Tags: Short Communication Source Type: research