Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease: Pathogenesis and Therapeutic Targets

Calcium (Ca2+) homeostasis is a critical determinant of cellular function and survival. Endoplasmic reticulum (ER) acts as the largest intracellular Ca2+ store that maintains Ca2+ homeostasis through ER Ca2+ uptake pump, sarco/ER –Ca2+ ATPase (SERCA), ER Ca2+ release channels, inositol 1,4,5-trisphosphate receptor channel (IP3R) and ryanodine receptor (RyR), and Ca2+-binding proteins inside the ER lumen. Alterations in ER homeostasis triggers ER Ca2+ depletion and ER stress, which is associated with development of a variet y of diseases.

Source: American Journal of Pathology - November 23, 2020 Category: Pathology Authors: Sun-Ji Park, Chuang Li, Ying Maggie Chen Tags: Mini-Review Source Type: research