Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus

AbstractSix new triterpene saponins (1–5,7) and 3 known saponins (6,8,9) were isolated from MeOH extracts of the cactusStenocereus pruinosus. The structures of the isolated saponins were elucidated using MS, IR, and comprehensive NMR measurements. To develop drugs for treating Alzheimer ’s disease (AD) on the basis of the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of BACE1 activity and amyloid beta (Aβ) aggregation using thioflavin-T assay, and triterpenes as an aglycone moiety and an alkaline hydrolysate of the saponins were also evaluated. One saponin, stenoside A (7), exhibited inhibitory activity related to A β aggregation and its degree of Aβ aggregation was 40.6% at 100 μM.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research