Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder.

Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder. Brain Behav Immun. 2020 Nov 19;: Authors: Green C, Shen X, Stevenson AJ, Conole ELS, Harris MA, Barbu MC, Hawkins EL, Adams MJ, Hillary RF, Lawrie SM, Evans KL, Walker RM, Morris SW, Porteous DJ, Wardlaw JM, Douglas Steele J, Waiter GD, Sandu AL, Campbell A, Marioni RE, Cox SR, Cavanagh J, McIntosh AM, Whalley HC Abstract Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD); however, the relationship between peripheral inflammation, brain structure and depression remains unclear, partly due to complexities around the use of acute/phasic inflammatory biomarkers. Here, we report the first large-scale study of both serological and methylomic signatures of CRP (considered to represent acute and chronic measures of inflammation respectively) and their associations with depression status/symptoms, and structural neuroimaging phenotypes (T1 and diffusion MRI) in a large community-based sample (Generation Scotland; NMDD cases=271, Ncontrols=609). Serum-CRP was associated with overall MDD severity, and specifically with current somatic symptoms- general interest (β= 0.145, PFDR = 6×10-4) and energy levels (β= 0.101, PFDR = 0.027), along with reduced entorhinal cortex thickness (β= -0.095, PFDR = 0.037). DNAm CRP was significantly associated with reduced global grey matter/cortical volume and widesp...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research