Microglia depletion increase brain injury after acute ischemic stroke in aged mice.

In conclusion, PLX5622 and AFS98 treatment depleted microglia in aged animals but resulted in increased neuroinflammation after ischemic stroke. PMID: 33221396 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33221396?dopt=Abstract

Source: Experimental Neurology - November 19, 2020 Category: Neurology Authors: Lee SM, Hudobenko J, McCullough LD, Chauhan A Tags: Exp Neurol Source Type: research