Exosome-mediated drug delivery for cell-free therapy of osteoarthritis.

Exosome-mediated drug delivery for cell-free therapy of osteoarthritis.
Curr Med Chem. 2020 Nov 18;:
Authors: Duan L, Xu X, Xu L, Chen H, Li X, Alahdal M, Xiao Y, Liang Y, Xia J
Abstract
Osteoarthritis (OA) is a degenerative disease of cartilage and bones, which results in severely compromised quality of life in the aged population. However, currently no ideal treatment strategies have been developed to prevent the OA progression. Cell therapies such as chondrocyte and MSC transplantation have been extensively tested and evaluated in clinical trials. Yet, until to date, the clinical efficacy of articular injection of stem cells in OA has not been convincingly demonstrated. Recent studies have indicated that exosomes, one type of Extracellular Vesicles (EVs) play an important regulatory role in the pathogenesis of OA, suggesting the prospective therapeutic application of exosomes in OA treatment. In this review, we systematically summarized the paracrine effects of exosomes derived from MSCs and chondrocytes on cartilage regeneration, the use of exosomes as a delivery vehicle for OA treatment, the effectiveness of such treatments in OA animal models, and future perspective of exosome-mediated drug delivery as a cell-free therapy of OA.
PMID: 33213308 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - November 18, 2020 Category: Chemistry Authors: Duan L, Xu X, Xu L, Chen H, Li X, Alahdal M, Xiao Y, Liang Y, Xia J Tags: Curr Med Chem Source Type: research