Divergent functionalization of terminal alkynes enabled alkynylative [5+1] benzannulation of 3-acetoxy-1,4-enynes.

Divergent functionalization of terminal alkynes enabled alkynylative [5+1] benzannulation of 3-acetoxy-1,4-enynes.
Chem Commun (Camb). 2020 Nov 21;:
Authors: Wu LJ, Yang LF, Lv GF, Li JH
Abstract
We here describe an alkynylative [5+1] benzannulation of 3-acetoxy-1,4-enynes with terminal alkynes, which enables both the construction of a benzene ring skeleton and intermolecular incorporation of an alkynyl group in a single reaction using Pd and Cu cooperative catalysts. The method represents efficient access to internal aryl alkynes through divergent functionalization of two terminal alkyne components: one alkyne serves as the one-carbon unit to realize the [5+1] benzannulation and the other alkyne as a nucleophile terminates the reaction.
PMID: 33220665 [PubMed - as supplied by publisher]

Source: Chemical Communications - November 21, 2020 Category: Chemistry Authors: Wu LJ, Yang LF, Lv GF, Li JH Tags: Chem Commun (Camb) Source Type: research