Angiotensin II, oxidative stress, and stem cell therapy: a matter of delicacy

Optimisation of stem cell therapy after cardiovascular and renal injury depends on many factors, amongst which stem cell donor health. The renin-angiotensin system (RAS), plays an important role in cardiovascular and renal homeostasis and pathophysiology. It is becoming increasingly clear that the RAS affects the therapeutic performance of stem cells. In the present issue of Clinical Science Kankuri et al. dig deeper into the consequences of excessive angiotensin II signaling and reactive oxygen species (ROS) formation in the stem cell donor, applying a model of regenerative medicine after renal injury.
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research