Angiotensin II, oxidative stress, and stem cell therapy: a matter of delicacy

Optimisation of stem cell therapy after cardiovascular and renal injury depends on many factors, amongst which stem cell donor health. The renin-angiotensin system (RAS), plays an important role in cardiovascular and renal homeostasis and pathophysiology. It is becoming increasingly clear that the RAS affects the therapeutic performance of stem cells. In the present issue of Clinical Science Kankuri et al. dig deeper into the consequences of excessive angiotensin II signaling and reactive oxygen species (ROS) formation in the stem cell donor, applying a model of regenerative medicine after renal injury.
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research

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Publication date: Available online 16 October 2019Source: Chemico-Biological InteractionsAuthor(s): Yasmeen M. Attia, Dina M. El-Kersh, Reham A. Ammar, Aliaa Adel, Aya Khalil, Hoda Walid, Kirullos Eskander, Mohamed Hamdy, Nada Reda, Nour Elhoda Mohsen, Ghada M. Al-Toukhy, Mohamed Tarek Mansour, Mohamed M. ElmazarAbstractTreatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms implicated in chemoresistance. Increased aldehyde dehro...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Condition:   Knee Osteoarthritis Interventions:   Biological: Low Dose of Mesenchymal stem cell;   Biological: High Dose of Mesenchymal stem cell;   Drug: Sodium Hyaluronate Sponsor:   CAR-T (Shanghai) Biotechnology Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
ConclusionThis study reiterates the importance of individual profiling of gut microbiota in HSCT patients.
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Larger business analysis concerns are starting to notice that the longevity industry exists. I point out this press release not because the contents are all that interesting or useful - it is very much business as usual in the white paper production community, and the people creating these materials typically have a poor understanding of the biology and the biotechnology - but rather as an indication of progress towards a broader appreciation of the potential to treat aging as a medical condition. Slowly, the eyes of the world are opened. The global longevity and anti-senescence market will witness rapid growth ov...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Contributors : Ronghui Li ; Yang Yu ; Cuiqing Zhong ; Jun Wu ; Juan Carlos Izpisua BelmonteSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA single mouse blastomere from until 8-cell embryo can generate an entire blastocyst. Whether blastomere-like extended pluripotent stem cells (EPS cells) retain a similar generative capacity remains unknown. Here, we established a 3D differentiation system that enabled the generation of blastocyst-like structures from EPS cells (EPS-blastoids) through lineage segregation and self-organization. EPS-blastoids resembled blastocysts in morphology and c...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionsDysregulation of liver developmental miRNAs, which exert a tumor suppressant effect, in EpCAM-positive HpSCs may contribute to liver carcinogenesis by promoting the transformation of HpSCs to CSCs of HB and HCC.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
The host-pathogen interface is a crucial battleground during bacterial infection in which host defenses are met with an array of bacterial counter-mechanisms whereby the invader aims to make the host environment more favorable to survival and dissemination. Interestingly, the eukaryotic Wnt signaling pathway has emerged as a key player in the host and pathogen tug-of-war. Although studied for decades as a regulator of embryogenesis, stem cell maintenance, bone formation, and organogenesis, Wnt signaling has recently been shown to control processes related to bacterial infection in the human host. Wnt signaling pathways con...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewWith the rapid and ongoing evolution of regenerative and sports medicine, the use of stem/stromal cells in ligament repair and reconstruction continues to be investigated and grow. The purpose of this review was to assess available methods and formulations for stem/stromal cell augmentation as well as review early pre-clinical and clinical outcomes for these recently emerging techniques.Recent FindingsRecent literature demonstrates promising outcomes of stem/stromal cell augmentation for ligament repair and reconstruction. Multiple groups have published animal models suggesting improved healing for...
Source: Current Reviews in Musculoskeletal Medicine - Category: Orthopaedics Source Type: research
Publication date: Available online 15 October 2019Source: Stem Cell ResearchAuthor(s): Silvin Lito, Patricie Burda, Matthias Baumgartner, Frédérique Sloan-Béna, Zsuzsanna Táncos, Julianna Kobolák, András Dinnyés, Karl-Heinz Krause, Antoine MarteynAbstractMucopolysaccharidosis type I-Hurler (MPS1-H) is the most severe form of inherited metabolic diseases caused by mutations in the IDUA gene. The resulting deficiency of alpha L-iduronidase enzyme leads to a progressive accumulation of glycosaminoglycans in lysosomes which damages multiple organs and highly reduces life expecta...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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