Reply to Comment on Rethinking the Hydroxychloroquine Dosing and Retinopathy Screening Guidelines

We read with interest the study by Browning and associates1 and are writing to highlight the highly variable pharmacokinetics of hydroxychloroquine (HCQ) and its potential implications in HCQ-induced retinopathy (HCQR). The authors stated daily dosage was the most important and only modifiable risk factor for HCQR. Despite being the most important risk factor for HCQR, the dose itself does not completely predict HCQ exposure. HCQ has a variable and incomplete absorption (30%-100%).2 The reported volume of distribution ranges from 153 liters to 47,247 liters.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research