Why Does A Virus Cause Problems In One Region But Not Another? A Study Offers Insight

In 2015, the mosquito-borne virus Zika exploded in South America. Health experts predicted it would erupt in Africa. But a major outbreak never happened. Now scientists think they understand why. (Image credit: James Gathany/CDC/Smith Collection/Gado/Getty Images)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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PMID: 33027394 [PubMed - in process]
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
D. Frentiu Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) cases has not been well characterized. Articles were extracted from PubMed and Scopus databases reporting original data from patients with arthralgia/arthritis, according to the Cochrane Collaboration. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 137 articles reporting ZIKV...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Anna Ramond, Ludmila Lobkowicz, Nuria Sanchez Clemente, Aisling Vaughan, Mar ília Dalva Turchi, Annelies Wilder-Smith, Elizabeth B. Brickley BackgroundRecent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentially vulnerable to ZIKV neurovirulence. MethodsWe conducted a systematic review on the clinical presentation and complications of children and adolescents aged 0 to 18 years with a ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Tyler M. Sharp, Talia M. Quandelacy, Laura E. Adams, Jomil Torres Aponte, Matthew J. Lozier, Kyle Ryff, Mitchelle Flores, Aidsa Rivera, Gilberto A. Santiago, Jorge L. Mu ñoz-Jordán, Luisa I. Alvarado, Vanessa Rivera-Amill, Myriam Garcia-Negrón, Stephen H. Waterman, Gabriela Paz-Bailey, Michael A. Johansson, Brenda Rivera-Garcia BackgroundAfter Zika virus (ZIKV) emerged in the Americas, laboratory-based surveillance for arboviral diseases in Puerto Rico was adapted to include ZIKV disease. Methods and findingsSuspected cases of arboviral disease reported to Puerto Rico Department of Health were teste...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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Source: Human and Ecological Risk Assessment - Category: Environmental Health Authors: Source Type: research
Background: The dengue virus (DENV) has been in circulation in Brazil for decades, resulting in the occurrence of several outbreaks. The emergence of Chikungunya virus (CHIKV) in 2014 and Zika virus (ZIKV) in 2015 has raised new concerns raised about the prevalence of these arboviruses. Concurrent outbreaks of DENV, CHIKV and ZIKV have taken place in Brazil since 2015, notably in major cities throughout the country's northeastern region. While the state of Bahia has been heavily affected by CHIKV and ZIKV outbreaks, the true burden of these infections remains hidden due to the predominance of asymptomatic infection.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0584 Source Type: research
Background: Since 2015, Zika virus (ZIKV) outbreaks have occurred in the Americas and the Pacific involving mosquito-borne and sexual transmission. ZIKV has also emerged as a risk to global blood transfusion safety. Aedes aegypti, a mosquito well established in north and some parts of central and southern Queensland, Australia, transmits ZIKV. Aedes albopictus, another potential ZIKV vector, is a threat to mainland Australia. Australia has not yet reported local transmission of ZIKV. However, due to the close proximity to, and frequent air traffic with many neighboring countries endemic for ZIKV, a history of imported case...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0582 Source Type: research
Background: Although Zika virus (ZIKV) infection causes a broad spectrum of congenital neurological disorders, radiographic correlates of clinical outcome are lacking. During 2015 –2016 ZIKV outbreak we faced a high incidence of microcephaly (MCP) in Rio Grande do Norte State (RN), located in northeast of Brazil. Among all regions, the northeast was the most affected by ZIKV. We aimed to identify distinct CT brain scan findings associated with congenital ZIKV infection and correlate them with neuro-clinical disorders in babies with MCP.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0575 Source Type: research
Background: Current trends of emerging infectious disease outbreaks (EIDs) forecast impending global epidemiological crises. Human-driven environmental changes, including climate change along with overpopulation and global travel, have been contributing to EIDs outbreaks in many developing countries. The subject has attracted increasing attention with the recent Ebola and Zika epidemics, which highlights the potential threats to human and animal health, social stability, and global trade and economy.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0523 Source Type: research
In this study, we further evaluated the broad-spectrum antiviral activity of the ten identified compounds by testing their activity against ZIKV. Among the ten compounds, Azaribine (SI-MTT = 146.29), AVN-944 (SI-MTT = 278.16), and Brequinar (SI-MTT = 157.42) showed potent anti-ZIKV activity in post-treatment therapeutic conditions. We also observed potent anti-ZIKV activity for Mycophenolate mofetil (SI-MTT = 20.51), Mycophenolic acid (SI-MTT = 36.33), and AVN-944 (SI-MTT = 24.51) in pre-treatment prophylactic conditions and potent co-treatment inhibitory activity for Obatoclax (SI-MTT = 60.58), Azaribine (SI-MTT = 91.51),...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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