Beyond “to divide or not to divide”: Kinetics matters in hematopoietic stem cells

A trillion blood cells are produced daily to maintain blood function at steady state. This immense regenerative output is achieved by the concerted action of rare and infrequently dividing hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). Decades of work, primarily in mouse models, have built complex roadmaps of the first steps of hematopoiesis by dissecting the cascade of cell divisions occurring from the most potent HSCs to multilineage and, in turn, unilineage progenitors. Recently, single-cell RNA-seq and clonal tracking have complemented these by defining differentiation trajectories at single-cell resolution [1].

Source: Experimental Hematology - November 11, 2020 Category: Hematology Authors: Carys Johnson, Serena Belluschi, Elisa Laurenti Tags: Perspective Source Type: research