Protein Kinase C Alpha (PKC α) overexpression leads to a better response to retinoid acid therapy through Retinoic Acid Receptor Beta (RARβ) activation in mammary cancer cells

ConclusionHere we propose that retinoids could lead a highly personalized anticancer treatment, bringing benefits to patients with aggressive breast tumors resulting from high PKC α expression but, an adequate expression of the RARβ receptor is required to ensure the effect on this process.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research