Nicotinic receptor modulation of the default mode network

ConclusionsThe finding that nAChR tone reduction by mecamylamine weakened task-induced DMN deactivation indicates that a constant tone of nAChR activation helps regulate DMN activity in healthy individuals. This suggests that low nAChR tone may play a causal role in DMN dysregulation seen in conditions such as mild cognitive impairment or Alzheimer ’s disease.
Source: Psychopharmacology - Category: Psychiatry Source Type: research