Nicotinic receptor modulation of the default mode network
ConclusionsThe finding that nAChR tone reduction by mecamylamine weakened task-induced DMN deactivation indicates that a constant tone of nAChR activation helps regulate DMN activity in healthy individuals. This suggests that low nAChR tone may play a causal role in DMN dysregulation seen in conditions such as mild cognitive impairment or Alzheimer ’s disease.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
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