Endothelialitis plays a central role in the pathophysiology of severe COVID-19 and its cardiovascular complications.

Endothelialitis plays a central role in the pathophysiology of severe COVID-19 and its cardiovascular complications. Acta Cardiol. 2020 Nov 19;:1-16 Authors: Vrints CJM, Krychtiuk KA, Van Craenenbroeck EM, Segers VF, Price S, Heidbuchel H Abstract This clinical review paper discusses the pathophysiology of the pulmonary and cardiovascular manifestations of a SARS-CoV-2 infection and the ensuing implications on acute cardiovascular care in patients presenting with a severe COVID-19 syndrome admitted to an intensive acute cardiac care unit. The high prevalence of old age, obesity, diabetes, hypertension, heart failure, and ischaemic heart disease in patients who develop a severe to critical COVID-19 syndrome suggests shared pathophysiological mechanisms. Pre-existing endothelial dysfunction and an impaired innate immune response promote the development by the viral infection of an acute endothelialitis in the pulmonary microcirculation complicated by abnormal vasoconstrictor responses, luminal plugging by inflammatory cells, and intravascular thrombosis. This endothelialitis extends into the systemic circulation what may lead to acute myocardial injury, myocarditis, and thromboembolic complications both in the arterial and venous circulation. Ever since the first case reports from the city of Wuhan in China in December of 2019, coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues as a ragin...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research

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AbstractChronic thromboembolic pulmonary hypertension is an underdiagnosed condition. Patients typically present with the symptoms of right heart failure. Diagnosis is usually done by radionuclide ventilation/perfusion (VQ) scan, high-quality multidetector computed tomography (CT) or pulmonary angiography at expert centers. Pulmonary endarterectomy remains the corner stone in management of chronic thromboembolic pulmonary hypertension. Deep hypothermic circulatory arrest is commonly used for the operation at most centers. In-hospital mortality ranges from 1.7 to 14.2%. Pulmonary hemorrhage, reperfusion lung injury, and rig...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
COVID-19 deaths per day have begun to creep back up again after a decline that started in late September.Associated Press
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Commenting on the announcement that the government is to end the public sector pay freeze UNISON general secretary Christina McAnea said: “There’s never a good time to freeze public sector pay. Doing so at the peak of a pandemic was the height of folly. “Staff were doing their all to keep under-pressure services running, and ministers looked like they didn’t care. “There can be no decent public services without the people to run them. Pay freezes don’t help employers hold on to experienced staff, nor attract new recruits. “But if the chancellor doesn’t allocate...
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Oct 27, 2021. . Sponsored by Center for Homeland Defense and Security
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This study aims to examine the consequent changes in medical school curricula alongside students’ mental and physical health. It is observed that 549 medical students (response rate: 79.7%) from 31 of 37 public medical schools in Germany completed a cross-sectional online survey. Students answered questions regarding teaching, internet use, COVID-19 and well-being. A multivariate logistic regression examined factors associated with depressed mood, insomnia and headache. Academic teaching moved to a virtual environment (91%), whilst practical activities were suspended or cancelled (88%). Virtual teaching modalit...
Source: The Journal of Mental Health Training, Education and Practice - Category: Psychiatry & Psychology Authors: Source Type: research
Wichita State University is one of the latest in Wichita to announce a new Covid-19 vaccine requirement for all of its employees based on a federal mandate from President Joe Biden. In an email sent to faculty and staff on Friday, WSU announced it will require all employees — including full- and part-time workers, as well as student employees — to be fully vaccinated by Dec. 8, regardless of whether or not they work on campus or remotely. WSU employs about 2,500 employee s. "Vaccination of…
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Tumbling COVID-19 case counts have some schools around the U.S. considering relaxing their mask rules, but deaths nationally have been ticking up over the past few weeks
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Nov 17, 2021. US. Sponsored by Indiana Rural Health Association
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A major gap exists in the present spectrum of efforts to develop the means to treat aging, rejuvenate the old, and turn back age-related conditions. An the one hand, a small number of promising potential therapies to treat the mechanisms of aging can at present be applied by physicians off-label, or otherwise without the need for a great deal of interaction with the FDA. On the other hand, there are a good hundred or more clinical indications, specific age-related conditions recognized by regulatory authorities, that might be improved by these therapies. Several hundred small, informal trials could be run, starting now, gi...
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