Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis.

Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis. CNS Neurol Disord Drug Targets. 2020 Nov 17;: Authors: Zhao L, Gao Y, Guo S, Lu X, Yu S, Ge ZZ, Zhu HD, Li Y Abstract Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review ex-plores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia ac-tivation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopa-thy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies. PMID: 33208082 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research