Comprehensive plasma metabolites profiling reveals phosphatidylcholine species as potential predictors for cardiac resynchronization therapy response

ConclusionsPatients with HF held significantly altered plasma metabolomics profile compared with the healthy individuals. Within the HF group, the non ‐responders had a distinct plasma metabolomics profile in contrast to the responders to CRT, which was characterized by increased PCs species. A novel predictive model incorporating four PCs metabolites performed well in identifying CRT non‐responders. These four PCs might severe as potential bi omarkers for predicting CRT response. Further validations are needed in multi‐centre studies with larger external cohorts.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research