Urea transporter proteins as targets for small-molecule diuretics

Nature Reviews Nephrology 11, 113 (2015). doi:10.1038/nrneph.2014.219 Authors: Cristina Esteva-Font, Marc O. Anderson & Alan S. Verkman Conventional diuretics such as furosemide and thiazides target salt transporters in kidney tubules, but urea transporters (UTs) have emerged as alternative targets. UTs are a family of transmembrane channels expressed in a variety of mammalian tissues, in particular the kidney. UT knockout mice and humans
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Review Source Type: research