Glomerular disease: Autophagy failure and mitochondrial dysfunction in FSGS

Nature Reviews Nephrology 11, 66 (2015). doi:10.1038/nrneph.2014.233 Author: Ellen F. Carney Researchers report that failure of autophagy may be a central mechanism in the pathogenesis of focal segmental glomerulosclerosis (FSGS). Jeremy Duffield and colleagues showed that abrogation of autophagic pathways in murine nephrons is sufficient to recreate many of the characteristic features of the human disease.

http://feeds.nature.com/~r/nrneph/rss/current/~3/KenmzaMi3gk/nrneph.2014.233

Source: Nature Reviews Nephrology - December 9, 2014 Category: Urology & Nephrology Authors: Ellen F. Carney Tags: Research Highlight Source Type: research

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