Transplantation: Induction of chimerism and immune tolerance using belatacept

Nature Reviews Nephrology 11, 66 (2015). doi:10.1038/nrneph.2014.230 Author: Ellen F. Carney A new study has demonstrated successful induction of transient mixed chimerism and long-term renal allograft tolerance in cynomolgus monkeys using a conditioning regimen that includes belatacept. This CTLA4–Ig fusion protein blocks T-cell costimulation by binding to B7 molecules expressed on antigen presenting cells.Researcher Tatsuo
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research