Transplantation: Induction of chimerism and immune tolerance using belatacept
Nature Reviews Nephrology 11, 66 (2015).
doi:10.1038/nrneph.2014.230
Author: Ellen F. Carney
A new study has demonstrated successful induction of transient mixed chimerism and long-term renal allograft tolerance in cynomolgus monkeys using a conditioning regimen that includes belatacept. This CTLA4–Ig fusion protein blocks T-cell costimulation by binding to B7 molecules expressed on antigen presenting cells.Researcher Tatsuo
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Ellen F. Carney Tags: Research Highlight Source Type: research