Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue
Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue Prostate Cancer and Prostatic Diseases advance online publication, January 27 2015. doi:10.1038/pcan.2014.54 Authors: J G Baust, J C Bischof, S Jiang-Hughes, T J Polascik, D B Rukstalis, A A Gage &J M Baust
CONCLUSION: Surgeon's personal experiences has a significant impact on the decision-making processes during preoperative assessments. However, non-patient factors such as institutional microcultures passively and actively influence decision-making process during preoperative assessment. PMID: 31872469 [PubMed - indexed for MEDLINE]
AbstractObjectivesConventional spin-echo (SE) DWI leads to a fundamental trade-off depending on theb value: highb value provides better lesion contrast-to-noise ratio (CNR) by sacrificing signal-to-noise ratio (SNR), image quality, and quantitative reliability. A stimulated-echo (STE) DWI acquisition is evaluated for high-CNR imaging of prostate cancer while maintaining SNR and reliable apparent diffusion coefficient (ADC) mapping.MethodsIn this prospective, IRB-approved study, 27 patients with suspected prostate cancer (PCa) were scanned with three DWI sequences (SEb = 800 s/mm2, SEb = 150...
An increasing number of men diagnosed with localised prostate cancer has been accompanied by more men being considered for active surveillance as a management option. Here the author provides an update on recent developments in active surveillance and changes to NICE guidance.
Publication date: Available online 14 February 2020Source: European UrologyAuthor(s): Maria Chiara Sighinolfi, Bernardo Rocco
This study included 74 Japanese patients with CRPC who were treated with cabazitaxel between 2014 and 2017. Associations between clinicopathological factors including serum markers and progression-free survival (PFS) and overall survival (OS) were investigated. On multivariate analysis, high Gleason score [≥9 vs. ≤7; hazard ratio (HR), 95% confidence interval (CI): 2.00 (1.01–4.34); P = 0.047], presence of pain [HR, 95% CI: 2.02 (1.14–3.58); P = 0.016], and lactate dehydrogenase (LDH) level [HR, 95% CI: 47.31 (3.79–577.49); P = 0.0019] were significantly associated with PFS. Similarly, number of doc...
This study is the first examining the interplay between Slit2 –Robo1–CXCR4 proteins and silymarin in DU145 cells. We believe that our study will provide new insights for future studies.
The study couldn't prove cause and effect, but it found that statins, taken alone or with metformin, did seem associated with an increase in survival.
Two drugs comparably improve survival in the treatment of men with hormone-sensitive prostate cancer, so researchers looked at quality of life to see whether that was a difference maker.Medscape Medical News
ConclusionTRT could be considered for most men with LOH regardless of their history of prostate disease. However, a discussion about the risks and benefits of TRT is always advised, especially in men with PCa. Appropriate monitoring is mandatory.
ConclusionIn patients with PSA serum levels of 4∼10 ng/mL, bpMRI and bpMRI combined with PSAD achieve better performance than mpMRI in detecting csPCa; bpMRI has a higher specificity than mpMRI, which could decrease unnecessary biopsy, and may serve as a potential alternative to mpMRI to optimize clinical workup.