The serological responses to acute exercise in humans reduce cancer cell growth in vitro: A systematic review and meta ‐analysis

This systematic review and meta ‐analysis showed that exercise‐conditioned serum significantly reduces in vitro cancer cell growth. This finding provides preliminary evidence that acute exercise‐induced modulations in serum markers may, at least in part, explain the link between regular physical activity and reduced cancer r isk. AbstractWe systematically reviewed and meta ‐analyzed the effects of acute exercise‐conditioned serum on cancer cell growth in vitro. Five literature databases were systematically searched for studies that measured cancer cell growth after exposure to human sera obtained before and immediately after an acute bout of exercise. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using a three‐level random‐effects model. Meta‐regressions were also performed with participant age and disease status, exercise type, cell lineTP53 status, and serum incubation time entered as covariates. Seven studies met the inclusion criteria encompassing a total of 21 effect estimates and 98 participants. Exercise ‐conditioned serum significantly reduced cancer cell growth compared with preexercise serum (SMD = −1.23, 95% CI: −1.96 to −0.50;p = .002;I2 = 75.1%). The weighted mean reduction as a percentage of preexercise values was 8.6%. The overall treatment effect and magnitude of heterogeneity were not statistically influenced by any covariate. There were concerns regarding the risk of bias within individual ...
Source: Physiological Reports - Category: Physiology Authors: Tags: REVIEW Source Type: research