Sperm ion channels and transporters in male fertility and infertility

Nature Reviews Urology, Published online: 19 November 2020; doi:10.1038/s41585-020-00390-9Mammalian sperm must respond to a variety of cues, and dynamic regulation of ion signalling is, therefore, essential for sperm cells to adapt to their environment. In this Review, the authors describe the ion channels and membrane receptors controlling sperm activity, in particular the principal Ca2+-selective plasma membrane ion channel CatSper, and consider how sperm ion channels and membrane receptors are attractive targets for therapeutics and how these signalling processes might have implications for assisted reproductive technologies.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research