Positron Emission Tomography Imaging of Functional Transforming Growth Factor β (TGFβ) Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors

Transforming growth factor β (TGFβ) promotes cell survival by endorsing DNA damage repair and mediates an immunosuppressive tumor microenvironment. Thus, TGFβ activation in response to radiation therapy is potentially targetable because it opposes therapeutic control. Strategies to assess this potential in the clinic are n eeded.

Source: International Journal of Radiation Oncology * Biology * Physics - September 29, 2020 Category: Radiology Authors: Alba Gonzalez-Junca, Oliver Reiners, Luis D. Borrero-Garcia, Denis Beckford-Vera, Ann A. Lazar, William Chou, Steve Braunstein, Henry VanBrocklin, Benjamin L. Franc, Mary Helen Barcellos-Hoff Tags: Biology Contribution Source Type: research