Cancers, Vol. 12, Pages 3441: Small Bowel Adenocarcinomas Featuring Special AT-Rich Sequence-Binding Protein 2 (SATB2) Expression and a Colorectal Cancer-Like Immunophenotype: A Potential Diagnostic Pitfall

Cancers, Vol. 12, Pages 3441: Small Bowel Adenocarcinomas Featuring Special AT-Rich Sequence-Binding Protein 2 (SATB2) Expression and a Colorectal Cancer-Like Immunophenotype: A Potential Diagnostic Pitfall Cancers doi: 10.3390/cancers12113441 Authors: Giuseppe Neri Giovanni Arpa Camilla Guerini Federica Grillo Marco Vincenzo Lenti Paolo Giuffrida Daniela Furlan Fausto Sessa Erica Quaquarini Alessandra Viglio Cristina Ubezio Alessandra Pasini Stefano Ferrero Gianluca Sampietro Sandro Ardizzone Giovanni Latella Claudia Mescoli Massimo Rugge Fabiana Zingone Valeria Barresi Rachele Ciccocioppo Paolo Pedrazzoli Gino Roberto Corazza Ombretta Luinetti Enrico Solcia Marco Paulli Antonio Di Sabatino Alessandro Vanoli Special AT-rich sequence-binding protein 2 (SATB2) is a transcription factor expressed by colonic cryptic epithelium and epithelial neoplasms of the lower gastrointestinal (GI) tract, as well as by small bowel adenocarcinomas (SBAs), though at a lower rate. Nevertheless, up to now, only small SBA series, often including a very limited number of Crohn’s disease-associated SBAs (CrD-SBAs) and celiac disease-associated SBAs (CD-SBA), have been investigated for SATB2 expression. We evaluated the expression of SATB2 and other GI phenotypic markers (cytokeratin (CK) 7 and CK20, caudal type homeobox 2 (CDX2) and alpha-methylacyl-CoA racemase (AMACR)), as well as mismatch repair (MMR) proteins, in 100 SBAs, ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research

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