Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1.

CONCLUSION: DMAKO-20 exhibited a selective cytotoxic effect on melanoma cells through CYP1B1-mediated activation. Using DMAKO-20 as a lead compound, further structural optimization may provide new drug entities for the treatments of malignant skin carcinomas. PMID: 33200710 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33200710?dopt=Abstract

Source: Current Cancer Drug Targets - November 15, 2020 Category: Cancer & Oncology Authors: Cui J, Zhou X, Huang J, Cui J, Chen J Tags: Curr Cancer Drug Targets Source Type: research