Increase in aflatoxin exposure in two populations residing in East and West Texas, United States.
In this study, two populations from East and West Texas, known for their high risk of liver cancer, were examined for their AF exposure at three different time periods from 2004 to 2014. Serum samples (n = 1124) were collected from participants recruited for various studies from Bexar County and Lubbock County, TX, over the span of 2004 through 2014. The exposure biomarker, serum AFB1-lysine adduct, was analyzed by HPLC-FLD and confirmed by LC-MS. Both populations showed a significant increase in detection rate, as well as median levels of serum AFB1-lysine adduct over time, from 2.35 to 4.34 pg/mg albumin in East Texas (2007-2014), and 0.63-3.98 pg/mg albumin in West Texas (2004-2010). This observed shift in exposure likely represents a shift in the AF contamination pattern in the State of Texas, and may warrant further studies on risk assessment for the potential etiological effects of such increased exposures.
PMID: 33197706 [PubMed - as supplied by publisher]
Source: International Journal of Hygiene and Environmental health - Category: Environmental Health Authors: Xue KS, Tang L, Shen CL, Pollock BH, Guerra F, Phillips TD, Wang JS Tags: Int J Hyg Environ Health Source Type: research
More News: Cancer | Cancer & Oncology | Diets | Environmental Health | International Medicine & Public Health | Liver | Nutrition | Study | Urology & Nephrology | USA Health