Dual roles of TGF- β signaling in the regulation of dental epithelial cell proliferation

In conclusions, TGF-β exhibits dual roles in the regulation of dental epithelial cell proliferation through two pathways. On the one hand, TGF-β activates canonical Smad2/3 signaling through ALK5, i nhibiting the proliferation of internal dental epithelial cells. On the other hand, TGF-β activates noncanonical Smad1/5 signaling through ALK1/2-ALK5, promoting the proliferation of basal cells in the dental epithelial bud.
Source: Journal of Molecular Histology - Category: Laboratory Medicine Source Type: research