Distinct Patterns of Repetition Suppression in Fragile X Syndrome, Down Syndrome, Tuberous Sclerosis Complex and Mutations in SYNGAP1.

Distinct Patterns of Repetition Suppression in Fragile X Syndrome, Down Syndrome, Tuberous Sclerosis Complex and Mutations in SYNGAP1. Brain Res. 2020 Nov 12;:147205 Authors: Côté V, Lalancette È, Knoth IS, Côté L, Agbogba K, Vannasing P, Major P, Barlaam F, Michaud J, Lippé S Abstract Sensory processing is the gateway to information processing and more complex processes such as learning. Alterations in sensory processing is a common phenotype of many genetic syndromes associated with intellectual disability (ID). It is currently unknown whether sensory processing alterations converge or diverge on brain responses between syndromes. Here, we compare for the first time four genetic conditions with ID using the same basic sensory learning paradigm. One hundred and five participants, aged between 3 to 30 years old, composing four clinical ID groups and one control group, were recruited : Fragile X syndrome (FXS; n=14), tuberous sclerosis complex (TSC; n=9), Down syndrome (DS; n=19), SYNGAP1 mutations (n=8) and Neurotypical controls (NT; n=55)). All groups included female and male participants. Brain responses were recorded using electroencephalography (EEG) during an audio-visual task that involved three repetitions of the pronunciation of the phoneme /a/. Event Related Potentials (ERP) were used to: 1) compare peak-to-peak amplitudes between groups, 2) evaluate the presence of repetition suppression within each group and 3) compa...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research