Overexpression of Protein Kinase M ζ in the Hippocampus Mitigates Alzheimer's Disease-Related Cognitive Deficit in Rats.

In conclusion, hippocampal overexpression of PKMζ restored memory dysfunction induced by amyloidopathy in part, through preserving hippocampal GluA2 containing AMPA receptors. PKMζ's signaling pathway could be considered as a therapeutic target to battle memory deficits in the early phase of AD.
PMID: 33188852 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - November 11, 2020 Category: Neurology Authors: Amini N, Azad RR, Motamedi F, Mirzapour-Delavar H, Ghasemi S, Aliakbari S, Pourbadie HG Tags: Brain Res Bull Source Type: research