Histone Deacetylase Inhibitors Prevented the Development of Morphine Tolerance by Decreasing IL6 Production and Upregulating μ-Opioid Receptors.

CONCLUSION: Results indicated that HDAC inhibitors were involved in the prevention of morphine tolerance in normal mice by inhibiting pro-inflammatory marker production and by increasing the sensitivity of neurons towards morphine in producing an analgesic effect in morphine tolerated mice. PMID: 33191889 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33191889?dopt=Abstract

Source: CNS and Neurological Disorders Drug Targets - November 12, 2020 Category: Drugs & Pharmacology Authors: Jindal S, Kumar N, Shah AA, Shah A, Gourishetti K, Rao CM Tags: CNS Neurol Disord Drug Targets Source Type: research