The effects of xenon on sevoflurane anesthesia-induced acidosis and brain cell apoptosis in immature rats.

The effects of xenon on sevoflurane anesthesia-induced acidosis and brain cell apoptosis in immature rats. Paediatr Anaesth. 2020 Nov 13;: Authors: Gill H, Pickering AE Abstract Anesthesia-induced neurodegeneration (AIN) occurs in newborn large animal modelswhere physiological homeostasis is maintained. However, most immature rodent models of AINreport mortality ratesand hypercarbia alone, mimicking that produced by anesthesia, increases neuro-apoptosis1 .Thepotential influence of physiological derangement is one reason why rodent models of AIN are notidealfor predicting clinical effect.However, they remain necessary for theinitial pre-clinical investigation of toxicity or treatment. PMID: 33187024 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research